Evaluation of HCV treatment in people who actively inject drugs. (July 2016)

• Record Type: Journal Article
• Authors: Alimohammadi, Arshia; Hakobyan, Syune; Raycraft, Tyler; Vafadary, Sahand; Conway, Brian
• Is Part Of: Future virology. Volume 11:Number 7(2016)
• Page Start: 483
• Page End: 487
• Publication Date: 2016-07
• Subjects: all-oral antiviral therapy -- chronic hepatitis C -- people who inject drugs; Virology -- Periodicals; Virus diseases -- Treatment -- Periodicals; 616.9101
• DOI: 10.2217/fvl-2016-0042
• Languages: English
• ISSNs: 1746-0794

Abstract

Aim: HCV treatment in people who actively inject drugs (PWID) (active PWID) is sometimes withheld. We propose that active PWID can be treated for HCV in the right setting.Methods: HCV-infected active PWID were evaluated at a multidisciplinary clinic in an observational study. The primary end point was a sustained virologic response following HCV therapy.Results: We included 40 active PWID, of which 63% used heroin, 70% used cocaine and 37% received all-oral regimens. With a mean follow-up of 570 days, 78% subjects achieved sustained virologic response (93% on all-oral regimens; p < 0.05), with no recurrent viremia.Conclusion: Active PWID can be effectively treated for HCV, especially with all-oral regimens and rates of recurrent viremia can be reduced in a multidisciplinary healthcare setting.