Association of polymorphisms in Dickopff (DKK) gene towards modulating risk for lung cancer in north Indians. (February 2017)

• Record Type: Journal Article
• Authors: Bahl, Charu; Singh, Navneet; Behera, Digambar; Sharma, Siddharth
• Is Part Of: Future oncology. Volume 13:Number 3(2017)
• Page Start: 213
• Page End: 232
• Publication Date: 2017-02
• Subjects: DKK -- lung cancer -- Wnt pathway; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2016-0117
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: To investigate the association between the genetic variants of DKK4 (rs2073664), DKK3 (rs2291599, rs3206824 and rs7391689) and DKK2 (rs447372, rs419558 and rs17037102) and lung cancer predisposition in north Indians.Materials & methods: A total of 600 subjects were genotyped using PCR restriction fragment length polymorphism technique. Association analysis was carried out using logistic regression approach.Results: DKK3 rs7396187 showed a protective effect (p = 0.01). Subjects with heterozygous genotype of DKK2 rs17037102 and rs419558 showed an increased risk. The variant genotype of the genotypic combination, DKK3 rs3206824 and DKK2 rs419558 showed a twofold increased risk (p = 0.008). Lung cancer risk increased four-times in subjects with variant genotype of all the three DKK2 variants.Conclusion: DKK2 is certainly playing a crucial role in modulating cancer susceptibility.