Sonidegib for the treatment of advanced basal cell carcinoma: a comprehensive review of sonidegib and the BOLT trial with 12-month update. (September 2016)

• Record Type: Journal Article
• Authors: Chen, Leon; Silapunt, Sirunya; Migden, Michael R
• Is Part Of: Future oncology. Volume 12:Number 18(2016)
• Page Start: 2095
• Page End: 2105
• Publication Date: 2016-09
• Subjects: basal cell carcinoma -- BOLT trial -- sonidegib; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2016-0118
• Languages: English
• ISSNs: 1479-6694

Abstract

The Hedgehog inhibitors are promising alternative for patients with advanced basal cell carcinoma that are not amenable to radiotherapy or surgery. Sonidegib, also known as LDE225, is an orally available SMO antagonist that was recently approved by the US FDA for the treatment of patients with locally advanced basal cell carcinoma. This article will provide an overview of the pharmacology and pharmacokinetics of sonidegib and in-depth analysis of the BOLT trial with additional data from the 12-month update. The present challenges associated with Hedgehog inhibitors will also be discussed.