Design and evaluation of an oral multiparticulate system for dual delivery of amoxicillin and Lactobacillus acidophilus. (September 2016)

• Record Type: Journal Article
• Authors: Govender, Mershen; Choonara, Yahya E; van Vuuren, Sandy; Kumar, Pradeep; du Toit, Lisa C; Pillay, Viness
• Is Part Of: Future microbiology. Volume 11:Number 9(2016:Sep.)
• Page Start: 1133
• Page End: 1145
• Publication Date: 2016-09
• Subjects: accelerated stability studies -- alternative therapies -- amoxicillin -- antibiotic and probiotic therapy -- Box–Behnken statistical design -- concurrent delivery -- cross-linked protein system -- delayed release system -- infectious disease therapeutics -- Lactobacillus acidophilus; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb-2016-0059
• Languages: English
• ISSNs: 1746-0913

Abstract

Aim: A delayed-release dual delivery system for amoxicillin and the probiotic Lactobacillus acidophilus was developed and evaluated.Materials & methods: Statistical optimization of a cross-linked denatured ovalbumin protective matrix was first synthesized using a Box–Behnken experimental design prior to encapsulation with glyceryl monostereate. The encapsulated ovalbumin matrix was thereafter incorporated with amoxicillin in a gastro-resistant capsule. In vitro characterization and stability analysis of the ovalbumin and encapsulated components were also performedResults: Protection of L. acidophilus probiotic against the bactericidal effects of amoxicillin within the dual formulation was determined.Conclusion: The dual formulation in this study proved effective and provides insight into current microbiome research to identify, classify and use functional healthy bacteria to develop novel probiotic delivery technologies.