Impact of QT interval prolongation following antiarrhythmic drug therapy on left ventricular function. (January 2017)

• Record Type: Journal Article
• Authors: Chouchoulis, Konstantinos; Chiladakis, John; Koutsogiannis, Nikolaos; Davlouros, Periklis; Kaza, Maria; Alexopoulos, Dimitrios
• Is Part Of: Future cardiology. Volume 13:Number 1(2017)
• Page Start: 13
• Page End: 22
• Publication Date: 2017-01
• Subjects: antiarrhythmic drug therapy -- left ventricular function -- QT interval prolongation; Cardiology -- Research -- Periodicals; 616.12005
• DOI: 10.2217/fca-2016-0052
• Languages: English
• ISSNs: 1479-6678

Abstract

Aim: We assessed whether antiarrhythmic drug-induced QT interval prolongation affects left ventricular function.Methods: Study population included 54 patients with symptomatic recent onset atrial fibrillation spontaneously cardioverted to sinus rhythm. Electrocardiographic and echocardiographic studies were done before initiating and after achieving drug's steady state.Results: Significantly prolonged corrected QT interval (QTc) was noticed following only sotalol and amiodarone. The corrected precontraction time increased after sotalol (p = 0.005) and amiodarone (p = 0.017), not propafenone (p = 0.139). Analysis results between ΔEF and ΔQTc, ΔEF and ΔQTc(p), ΔE/e′ and ΔQTc, ΔE/e′ and ΔQTc(p) for amiodarone group were (p = 0.66, p = 0.20, p = 0.66, p = 0.33), for sotalol (p = 0.36, p = 0.51, p = 0.44, p = 0.33) and for propafenone (p = 0.38, p = 0.12, p = 0.89, p = 0.61), respectively.Conclusion: QT interval prolongation following antiarrhythmic therapy does not affect significantly left ventricular function.