A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS. (November 2016)

• Record Type: Journal Article
• Authors: Schwarz, Konstantin; Singh, Satnam; Parasuraman, Satish Kumar; Bruce, Maggie; Shepstone, Lee; Feelisch, Martin; Minnion, Magdalena; Ahmad, Shakil; Horowitz, John; Dawson, Dana K; Frenneaux, Michael P
• Is Part Of: Future cardiology. Volume 12:Number 6(2016)
• Page Start: 617
• Page End: 626
• Publication Date: 2016-11
• Subjects: angina -- inorganic nitrate -- randomized controlled trial; Cardiology -- Research -- Periodicals; 616.12005
• DOI: 10.2217/fca-2016-0026
• Languages: English
• ISSNs: 1479-6678

Abstract

In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.