H3K4 acetylation, H3K9 acetylation and H3K27 methylation in breast tumor molecular subtypes. (July 2016)

• Record Type: Journal Article
• Authors: Judes, Gaëlle; Dagdemir, Aslihan; Karsli-Ceppioglu, Seher; Lebert, André; Echegut, Maureen; Ngollo, Marjolaine; Bignon, Yves-Jean; Penault-Llorca, Frédérique; Bernard-Gallon, Dominique
• Is Part Of: Epigenomics. Volume 8:Number 7(2016)
• Page Start: 909
• Page End: 924
• Publication Date: 2016-07
• Subjects: breast cancer -- H3 modifications -- St Gallen molecular subtypes; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi-2016-0015
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: Here, we investigated how the St Gallen breast molecular subtypes displayed distinct histone H3 profiles.Patients & methods: 192 breast tumors divided into five St Gallen molecular subtypes (luminal A, luminal B HER2-, luminal B HER2+, HER2+ and basal-like) were evaluated for their histone H3 modifications on gene promoters.Results: ANOVA analysis allowed to identify specific H3 signatures according to three groups of genes: hormonal receptor genes ( ERS1, ERS2, PGR ), genes modifying histones ( EZH2, P300, SRC3 ) and tumor suppressor gene ( BRCA1 ). A similar profile inside high-risk cancers (luminal B [HER2+], HER2+ and basal-like) compared with low-risk cancers including luminal A and luminal B (HER2-) were demonstrated.Conclusion: The H3 modifications might contribute to clarify the differences between breast cancer subtypes.