Acute hemolysis in a patient with a newly diagnosed glioblastoma. (July 2016)

• Record Type: Journal Article
• Authors: Murphy, Adrian G; Grossman, Stuart A
• Is Part Of: CNS oncology. Volume 5:Number 3(2016)
• Page Start: 125
• Page End: 129
• Publication Date: 2016-07
• Subjects: dapsone -- glioblastoma multiforme -- glucose-6-phosphate dehydrogenase deficiency (G6PD) -- hemolytic anemia; Central nervous system -- Tumors -- Periodicals; 616.99481
• DOI: 10.2217/cns-2015-0009
• Languages: English
• ISSNs: 2045-0907

Abstract

We describe a 62-year-old of Egyptian origin who presented with sudden, severe and symptomatic anemia requiring hospitalization shortly after beginning concurrent radiation and temozolomide for his newly diagnosed glioblastoma. He had also recently been started on steroids, anticonvulsants and Pneumocystis jirovecii prophylaxis. He was ultimately diagnosed with G6PD deficiency with an acute hemolytic anemia precipitated by dapsone. Screening for G6PD deficiency should be considered in high-risk patient populations where P . jirovecii prophylaxis is planned.