Healing of a soft tissue wound of the neck and jaw osteoradionecrosis using platelet gel. (July 2016)

• Record Type: Journal Article
• Authors: Piccin, Andrea; Di Pierro, Angela Maria; Tagnin, Mario; Russo, Carla; Fustos, Roland; Corvetta, Daisy; Primerano, Marco; Magri, Elena; Conci, Viviana; Gentilini, Ivo; Burchia, Evelin; Negri, Giovanni; Mazzoleni, Guido; Gastl, Günther; Fontanella, Fabrizio
• Is Part Of: Regenerative medicine. Volume 11:Number 5(2016)
• Page Start: 459
• Page End: 463
• Publication Date: 2016-07
• Subjects: plastic surgery -- platelet gel -- platelet-rich plasma -- radiodermatitis; Cellular therapy -- Periodicals; Stem cells -- Transplantation -- Periodicals; Degeneration (Pathology) -- Treatment -- Periodicals; Regeneration (Biology) -- Periodicals; 611.018
• DOI: 10.2217/rme-2016-0031
• Languages: English
• ISSNs: 1746-0751

Abstract

Aim: Bone osteoradionecrosis is a serious complication of radiation treatment. Current treatment approaches are not curative and treatment response is often poor leading to high social and healthcare costs.Case report: We report on the first case of osteoradionecrosis with successful restitutio ab integro by repeated administration of platelet gel (PLT-gel) and surgery in a critically ill patient. The administration of PLT-gel during a severe septic episode helped regeneration of bone and soft tissues, shortening the hospital stay of the patient. It was also noted that following applications of PLT-gel, both the use of morphine and the numbers of infective episodes were reduced.Conclusion: Additional studies are needed to confirm the promising effect of PLT-gel for the treatment of osteoradionecrosis.