Overcoming drug resistance with on-demand charged thermoresponsive dendritic nanogels. (January 2017)

• Record Type: Journal Article
• Authors: Molina, Maria; Wedepohl, Stefanie; Miceli, Enrico; Calderón, Marcelo
• Is Part Of: Nanomedicine. Volume 12:Number 2(2017)
• Page Start: 117
• Page End: 129
• Publication Date: 2017-01
• Subjects: doxorubicin carrier -- drug resistance -- semi-interpenetrated PNIPAM; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2016-0308
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: To develop nanogels (NG) able to modulate the encapsulation and release of drugs, in order to circumvent drug resistance mechanisms in cancer cells.Materials & methods: Poly- N -isopropylacrylamide–dendritic polyglycerol NG were semi-interpenetrated with 2-acrylamido-2-methylpropane sulfonic acid or (2-dimethylamino) ethyl methacrylate. Physico-chemical properties of the NGs as well as doxorubicin (DOXO) loading and release were characterized. Drug delivery performance was investigated in vitro and in vivo in a multidrug-resistant tumor model.Results: Both the DOXO loaded semi-interpenetrating polymer network NGs were more efficient in multidrug resistant cancer cell proliferation inhibition studies. In vivo, the DOXO loaded NG semi-interpenetrated with 2-acrylamido-2-methylpropane sulfonic acid was able to overcome drug resistance and reduce the tumor volume to about 25%.Conclusion: The innovative semi-interpenetrating polymer network NGs appear to be promising drug carriers for drug resistant cancer therapy.