Inhibition of breast cancer metastasis by paclitaxel-loaded pH responsive poly(β-amino ester) copolymer micelles. (January 2017)

• Record Type: Journal Article
• Authors: Chen, Yanjun; Yue, Qiaoxin; De, Gejing; Wang, Jie; Li, Zhenzhen; Xiao, Shuiming; Yu, Huatao; Ma, Hai; Sui, Feng; Zhao, Qinghe
• Is Part Of: Nanomedicine. Volume 12:Number 2(2017)
• Page Start: 147
• Page End: 164
• Publication Date: 2017-01
• Subjects: anticancer -- invasion -- metastasis -- migration -- paclitaxel -- poly(β-amino ester); Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2016-0335
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: Tumor metastasis is one of the leading causes of insufficient chemotherapy during cancer treatment. In this study, a poly( β -amino ester) derivate was developed to fabricate paclitaxel (PTX) entrapped pH-responsive copolymer micelles for inhibition of breast cancer metastasis.Materials & methods: PTX-loaded micelles were fabricated by thin film hydration method. The inhibition efficacy of the as-prepared micelles was evaluated on MDA-MB-231 cells and tumor bearing mice.Results: PTX-loaded micelles were successfully prepared. Such micelles could promote drug uptake and MDA-MB-231 cell deaths, and suppress tumor metastasis.Conclusion: The pH-responsive PTX-loaded micelles are promising candidates in developing stimuli triggered drug delivery systems in acidic tumor microenvironments with improved inhibitory effects on tumor metastasis.