Polyhydroxyalkanoate/carbon nanotube nanocomposites: flexible electrically conducting elastomers for neural applications. (October 2016)

• Record Type: Journal Article
• Authors: Vallejo-Giraldo, Catalina; Pugliese, Eugenia; Larrañaga, Aitor; Fernandez-Yague, Marc A; Britton, James J; Trotier, Alexandre; Tadayyon, Ghazal; Kelly, Adriona; Rago, Ilaria; Sarasua, Jose-Ramon; Dowd, Eilís; Quinlan, Leo R; Pandit, Abhay; Biggs, Manus JP
• Is Part Of: Nanomedicine. Volume 11:Number 19(2016)
• Page Start: 2547
• Page End: 2563
• Publication Date: 2016-10
• Subjects: elastomeric polymers -- MWCNTs -- neural interfaces -- PHA; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2016-0075
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: Medium chain length-polyhydroxyalkanoate/multi-walled carbon nanotube (MWCNTs) nanocomposites with a range of mechanical and electrochemical properties were fabricated via assisted dispersion and solvent casting, and their suitability as neural interface biomaterials was investigated.Materials & methods: Mechanical and electrical properties of medium chain length-polyhydroxyalkanoate/MWCNTs nanocomposite films were evaluated by tensile test and electrical impedance spectroscopy, respectively. Primary rat mesencephalic cells were seeded on the composites and quantitative immunostaining of relevant neural biomarkers, and electrical stimulation studies were performed.Results: Incorporation of MWCNTs to the polymeric matrix modulated the mechanical and electrical properties of resulting composites, and promoted differential cell viability, morphology and function as a function of MWCNT concentration.Conclusion: This study demonstrates the feasibility of a green thermoplastic MWCNTs nanocomposite for potential use in neural interfacing applications.