Biodistribution and toxicity of orally administered poly (lactic-co-glycolic) acid nanoparticles to F344 rats for 21 days. (July 2016)

• Record Type: Journal Article
• Authors: Navarro, Sara M; Morgan, Timothy W; Astete, Carlos E; Stout, Rhett W; Coulon, Diana; Mottram, Peter; Sabliov, Cristina M
• Is Part Of: Nanomedicine. Volume 11:Number 13(2016)
• Page Start: 1653
• Page End: 1669
• Publication Date: 2016-07
• Subjects: biodistribution -- nanoparticles -- toxicity; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2016-0022
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: Quantify the biodistribution and assess the toxicity of PLGA (poly-lactic-co-glycolic acid) and surface-modified PLGA chitosan (PLGA/Chi) nanoparticles (NPs) orally administered for 7, 14 and 21 days to F344 rats.Materials & methods: Fluorescent NPs were tracked in F344 rat tissues, and toxicity was evaluated by alkaline phosphatase and alanine transaminase levels, and by histologic examination of tissue samples.Results: Biodistribution of PLGA and PLGA/Chi were similar, with highest amounts found in the intestine and liver. Alkaline phosphatase increased significantly in treated rats. Mild histological differences were detected in the intestine and liver.Conclusion: PLGA and PLGA/Chi NPs behaved similarly presenting minimal toxicity in the liver and intestine, but not in kidney, lung and brain.