A letter to the editor, associated with the article entitled "Efficacy and tolerability of combination treatments for major depression: Antidepressants plus second-generation antipsychotics vs esketamine vs lithium" by Vázquez et al. (Journal of Psychopharmacology, 2021, Vol. 35(8) 890–900). (May 2022) - Terao, Itsuki; Honyashiki, Mina; Inoue, Takeshi