Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus. (December 2021)

• Record Type: Journal Article
• Authors: Borrás, Consuelo; Abdelaziz, Kheira M.; Díaz, Ana; Gambini, Juan; Jové, Mariona; López-Grueso, Raul; Mas-Bargues, Cristina; Monleón, Daniel; Pamplona, Reinald; Viña, Jose
• Is Part Of: Mechanisms of ageing and development. Volume 200(2021)
• Publication Date: 2021-12
• Subjects: Isoflavones -- Soya -- Longevity -- Goto Kakizaki rats -- Antioxidant enzymes; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2021.111596
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: Lifelong soya feeding does not increase lifespan in healthy mice. Lifelong soya feeding increases antioxidant enzyme expression and activity. Soya feeding increases health span in diabetic rats. Abstract: Soya consumption can decrease oxidative stress in animal models. Moreover, phytoestrogens such as genistein, present in soya, can mimic some of the beneficial effects of estrogens and are devoid of significant side effects, such as cancer. In this study, we have performed a controlled lifelong study with male OF1 mice that consumed either a soya-free diet or a soya-rich diet. We show that, although we found an increase in the expression and activity of antioxidant enzymes in soya-consuming mice, it did not increase lifespan. We reasoned that the soya diet could not increase lifespan in a very healthy population, but perhaps it could extend health span in stressed animals such as type 2 diabetic Goto Kakizaki (GK) rats. Indeed, this was the case: we found that male GK rats consuming a soya-rich diet developed the disease at a lower rate and, therefore, lived longer than soya-free diet-consuming rats.