Antimicrobial peptide delivery: an emerging therapeutic for the treatment of burn and wounds. (23rd April 2018)

• Record Type: Journal Article
• Authors: Javia, Ankit; Amrutiya, Jitendra; Lalani, Rohan; Patel, Vivek; Bhatt, Priyanka; Misra, Ambikanandan
• Is Part Of: Therapeutic delivery. Volume 9:Number 5(2018)
• Page Start: 375
• Page End: 386
• Publication Date: 2018-04-23
• Subjects: antimicrobial peptide -- anti-inflammatory -- bacterial resistance -- burns -- cathelicidins -- immunomodulatory activity -- liposomes -- nanoparticles -- skin infections -- wounds; Drug delivery systems -- Periodicals; Therapeutics -- Periodicals; 615.6
• DOI: 10.4155/tde-2017-0061
• Languages: English
• ISSNs: 2041-5990

Abstract

The management of wounds and burns is becoming difficult using conventional therapeutics available due to resistance development by microbes. Therefore, there is an utmost need to develop therapeutic alternatives to these agents. Antimicrobial peptides have emerged as a novel class of agents for the effective management of wounds and burns due to their potent nature along with minimal chances of resistance development against them. This article focuses on highlighting the importance of these antimicrobial peptides among the various therapeutic alternatives for burns and wounds. Further, effective delivery strategies for these agents that are being employed and investigated are reported along with an overview of the importance of these agents in the coming years.