Navigating pleiotropy in precision medicine: pharmacogenes from trauma to behavioral health. (April 2016)

• Record Type: Journal Article
• Authors: Oberg, Vicki; Differding, Jerome; Fisher, Morgan; Hines, Lindsay; Wilke, Russell A
• Is Part Of: Pharmacogenomics. Volume 17:Number 5(2016)
• Page Start: 499
• Page End: 505
• Publication Date: 2016-04
• Subjects: Best Practice Advisory -- clinical decision support -- drug metabolizing enzyme -- electronic medical record -- individualized medicine -- personalized medicine -- pharmacodynamics -- pharmacogenes -- pharmacogenetics -- pharmacogenomics -- pharmacokinetics -- pleiotropy -- precision medicine; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs.16.6
• Languages: English
• ISSNs: 1462-2416

Abstract

A strong emerging principle in the field of precision medicine is that variation in any one pharmacogene may impact clinical outcome for more than one drug. Variants tested in the acute care setting often have downstream implications for other drugs impacting chronic disease management. A flexible framework is needed as clinicians and scientists move toward deploying automated decision support for gene-based drug dosing in electronic medical records.