In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing. (May 2016)

• Record Type: Journal Article
• Authors: Santos, Lívia; Silva, Marta; Gonçalves, Ana I.; Pesqueira, Tamagno; Rodrigues, Márcia T.; Gomes, Manuela E.
• Is Part Of: Nanomedicine. Volume 11:Number 9(2016)
• Page Start: 1107
• Page End: 1122
• Publication Date: 2016-05
• Subjects: electromagnetic fields -- magnetic responsive biomaterials -- regenerative medicine; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2015-0014
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim : To expand our understanding on the effect of magnetically actuated biomaterials in stem cells, inflammation and fibrous tissue growth.Materials & methods : Magnetic biomaterials were obtained by doping iron oxide particles into starch poly-ϵ-caprolactone (SPCL) to create two formulations, magSPCL-1.8 and 3.6. Stem cell behavior was assessed in vitro and the inflammatory response, subcutaneously in Wistar rats.Results : Metabolic activity and proliferation increased significantly overtime in SPCL and magSPCL-1.8. Electromagnetic fields attenuated the presence of mast cells and macrophages in tissues surrounding SPCL and magSPCL-1.8, between weeks 1 and 9. Macrophage reduction was more pronounced for magSPCL-1.8, which could explain why this material prevented growth of fibrous tissue overtime.Conclusion : Magnetically actuated biomaterials have potential to modulate inflammation and the growth of fibrous tissue.