Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis. Issue 2 (14th September 2021)

• Record Type: Journal Article
• Authors: Whalen, William; Buyukozkan, Mustafa; Moore, Bethany; Moon, Jong-Seok; Dela Cruz, Charles S; Martinez, Fernando J; Choi, Augustine M K; Krumsiek, Jan; Stout-Delgado, Heather; Cho, Soo Jung
• Is Part Of: Thorax. Volume 77:Issue 2(2022)
• Page Start: 186
• Page End: 190
• Publication Date: 2021-09-14
• Subjects: idiopathic pulmonary fibrosis; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2021-217315
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccf-double-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF.