Antimicrobial activity of topically-applied soyaethyl morpholinium ethosulfate micelles against Staphylococcus species. (March 2016)

• Record Type: Journal Article
• Authors: Yang, Shih-Chun; Aljuffali, Ibrahim A; Sung, Calvin T; Lin, Chwan-Fwu; Fang, Jia-You
• Is Part Of: Nanomedicine. Volume 11:Number 6(2016)
• Page Start: 657
• Page End: 671
• Publication Date: 2016-03
• Subjects: antimicrobial -- methicillin-resistant S. aureus -- micelle -- skin -- soyaethyl morpholinium ethosulfate; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.15.217
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: Here we evaluated the antibacterial efficacy of soyaethyl morpholinium ethosulfate (SME) micelles as an inherent bactericide against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA).Methodology: The antimicrobial activity was examined by in vitro culture model and murine model of skin infection. Cationic micelles formed by benzalkonium chloride or cetylpyridinium chloride were used for comparison.Results: The minimum inhibitory concentration and minimum bactericidal concentration against S. aureus and MRSA were 1.71–3.42 and 1.71–6.84 μg/ml, respectively. Topical administration of SME micelles significantly decreased the cutaneous infection and MRSA load in mice. The killing of bacteria was caused by direct cell wall/membrane rupture. SME micelles also penetrated into the bacteria to elicit a Fenton reaction and oxidative stress.Conclusion : SME micelles have potential as antimicrobial agents due to their lethal effect against S. aureus and MRSA with a low toxicity to mammalian cells.