Hypersensitivity in functional gastrointestinal disorders. (1st July 2002)

• Record Type: Journal Article
• Authors: Azpiroz, F
• Is Part Of: Gut. Volume 51(2002)Supplement 1
• Page Start: i25
• Page End: i28
• Publication Date: 2002-07-01
• Subjects: visceral hypersensitivity -- visceral reflexes -- functional dyspepsia -- irritable bowel syndrome -- functional gastrointestinal disorders; IBS, irritable bowel syndrome; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.51.suppl_1.i25
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Patients with functional gastrointestinal disorders may have visceral sensory dysfunction so that physiological stimuli induce their symptoms. The clinical significance of altered perception—that is, its relation to clinical symptoms—remains unclear. Data indicate that sensory dysfunction is associated with altered reflex activity. Hence evidence of combined sensory-reflex dysfunction as a common pathophysiological mechanism in various functional gastrointestinal disorders would suggest that they are different forms of the same process. Altered reflex activity and altered conscious perception of gastrointestinal stimuli may combine to differing degrees, and their interaction may produce clinical symptoms.