Electroconvulsive therapy for depression in Parkinson's disease: systematic review of evidence and recommendations. (April 2016)

• Record Type: Journal Article
• Authors: Borisovskaya, Anna; Bryson, William Culbertson; Buchholz, Jonathan; Samii, Ali; Borson, Soo
• Is Part Of: Neurodegenerative disease management. Volume 6:Number 2(2016)
• Page Start: 161
• Page End: 176
• Publication Date: 2016-04
• Subjects: electroconvulsive therapy -- major depressive disorder -- Parkinson's disease; Nervous system -- Degeneration -- Periodicals; 616.8
• DOI: 10.2217/nmt-2016-0002
• Languages: English
• ISSNs: 1758-2024

Abstract

Aim: We performed a systematic review of evidence regarding treatment of depression in Parkinson's disease (PD) utilizing electroconvulsive therapy.Methods: The search led to the inclusion of 43 articles, mainly case reports or case series, with the largest number of patients totaling 19.Results: The analysis included 116 patients with depression and PD; depression improved in 93.1%. Where motor symptoms' severity was reported, 83% of patients improved. Cognition did not worsen in the majority (94%). Many patients experienced delirium or transient confusion, sometimes necessitating discontinuation of electroconvulsive therapy (ECT). Little is known about maintenance ECT in this population.Conclusion: ECT can benefit patients suffering from PD and depression. We recommend an algorithm for treatment of depression in PD, utilizing ECT sooner rather than later.