Increased incidence of thyroid cancer among breast cancer survivors: an analysis of the SEER-9 database (1973–2011). (February 2016)

• Record Type: Journal Article
• Authors: Kuo, Jennifer H; Chabot, John A; Lee, James A
• Is Part Of: International journal of endocrine oncology. Volume 3:Number 1(2016)
• Page Start: 21
• Page End: 31
• Publication Date: 2016-02
• Subjects: breast cancer -- breast cancer survivors -- incidence of thyroid cancer -- second primary malignancy -- second primary thyroid cancer -- SEER -- SEER database -- thyroid cancer; Endocrine glands -- Cancer -- Periodicals; 616.9944005
• DOI: 10.2217/ije.15.31
• Languages: English
• ISSNs: 2045-0869

Abstract

Aims: We sought to re-examine the incidence of thyroid cancer among breast cancer survivors by performing a population-based, cohort analysis using the SEER-9 database.Methods: We identified 704, 370 breast cancer patients, 49, 663 thyroid cancer patients and 1526 patients who developed thyroid cancer after breast cancer (B1T).Results: Risk for developing thyroid cancer is greatest among survivors diagnosed with breast cancer at age less than 50 years. In general, B1T patients are younger with smaller tumors, and have a greater percentage of invasive ductal carcinoma. They develop thyroid cancer at an older age, and have a greater percentage of aggressive subtypes.Conclusion: Recognition of this association between thyroid and breast cancer should prompt increased awareness in these cancer patient populations.