Quantifying the utility of single nucleotide polymorphisms to guide colorectal cancer screening. (February 2016)

• Record Type: Journal Article
• Authors: Jenkins, Mark A; Makalic, Enes; Dowty, James G; Schmidt, Daniel F; Dite, Gillian S; MacInnis, Robert J; Ait Ouakrim, Driss; Clendenning, Mark; Flander, Louisa B; Stanesby, Oliver K; Hopper, John L; Win, Aung K; Buchanan, Daniel D
• Is Part Of: Future oncology. Volume 12:Number 4(2016)
• Page Start: 503
• Page End: 513
• Publication Date: 2016-02
• Subjects: cancer screening -- colorectal cancer -- risk prediction -- single nucleotide polymorphisms; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.15.303
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: To determine whether single nucleotide polymorphisms (SNPs) can be used to identify people who should be screened for colorectal cancer.Methods: We simulated one million people with and without colorectal cancer based on published SNP allele frequencies and strengths of colorectal cancer association. We estimated 5-year risks of colorectal cancer by number of risk alleles.Results: We identified 45 SNPs with an average 1.14-fold increase colorectal cancer risk per allele (range: 1.05–1.53). The colorectal cancer risk for people in the highest quintile of risk alleles was 1.81-times that for the average person.Conclusion: We have quantified the extent to which known susceptibility SNPs can stratify the population into clinically useful colorectal cancer risk categories.