Epigenetic and genetic variations at the TNNT1 gene locus are associated with HDL-C levels and coronary artery disease. (March 2016)

• Record Type: Journal Article
• Authors: Guay, Simon-Pierre; Légaré, Cécilia; Brisson, Diane; Mathieu, Patrick; Bossé, Yohan; Gaudet, Daniel; Bouchard, Luigi
• Is Part Of: Epigenomics. Volume 8:Number 3(2016)
• Page Start: 359
• Page End: 371
• Publication Date: 2016-03
• Subjects: 19q13.42 -- cardiovascular disease -- DNA methylation -- dyslipidemia -- missing heritability -- SNP -- TNNT1 c.-20G>A polymorphism (rs9636153); Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi.15.120
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: To assess whether epigenetic and genetic variations at the TNNT1 gene locus are associated with high-density lipoprotein cholesterol (HDL-C) and coronary artery disease (CAD).Patients, materials & methods: TNNT1 DNA methylation and c.-20G>A polymorphism were genotyped in subjects with and without familial hypercholesterolemia (FH).Results: Lower TNNT1 DNA methylation levels were independently associated with lower HDL-C levels and with the TNNT1 c.-20G>A polymorphism. In FH men, carriers of the TNNT1 c.-20G>A polymorphism had lower HDL-C levels and an increased risk of CAD compared with noncarriers. In non-FH men, a higher TNNT1 DNA methylation level was associated with CAD.Conclusion: These results suggest that TNNT1 genetic and epigenetic variations are associated with HDL-C levels and CAD.