A targeted self-assembling photosensitizer nanofiber constructed by multicomponent coordination. (19th November 2021)

• Record Type: Journal Article
• Authors: Zhang, Qianqian; Xu, Jiawei; Peng, Jiayi; Liu, Zhonghua
• Is Part Of: Biomaterials science. Volume 10:Number 1(2022)
• Page Start: 114
• Page End: 123
• Publication Date: 2021-11-19
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d1bm01559a
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : The self-assembling CFTNFs not only showed excellent phototoxicity against HepG2 cells in vitro, but also showed an optimized tumor targeting ability, improved tumor accumulation and enhanced tumor growth inhibition. Abstract : Employing a peptide-based supramolecular photosensitizer nanofiber that combines the flexibility of a self-assembling short peptide and high spatiotemporal precision is a promising approach in photodynamic therapy (PDT). Herein, we developed a versatile multicomponent and multifunctional coordination self-assembling photosensitizer nanofiber based on the combination of a diphenylalanine (FF) short peptide, cell penetrating peptide 44 (CPP44) and 5-(4-aminophenyl)-10, 15, 20-triphenyl porphine (TPP-NH2 ), resulting in CPP44-FF-TPP-NH2 nanofibers (CFTNFs). Transmission electron microscopy observations showed the filamentous morphology of CFTNFs. Compared with free TPP-NH2, CFTNFs exhibited a higher cell uptake ability in HepG2 cells and a better tumor targeting ability in in vivo experiments. Furthermore, CFTNFs induced apoptosis and necrosis of more HepG2 cells in vitro and showed higher tumor growth inhibitory activity in vivo . In summary, these results indicated that CFTNFs could lead to greatly enhanced photodynamic treatment efficacy. Moreover, our study provides new opportunities for the development of peptide-based multicomponent coordination self-assembling photosensitizer nanofibers to enhance tumor-specific delivery and the anticancer efficiency.