Catalyst-free one-pot cascade cyclization: An efficient synthesis of isoindolobenzoxazinones and isoindoloquinazolinones derivatives. (8th January 2022)

• Record Type: Journal Article
• Authors: Li, Wenzhong; Wan, Baibai; Shi, Ran; Chen, Si; Li, Jiazhu; Wang, Fangzhen; Niu, Hexu; Xu, Xin-Ming; Wang, Wei-Li
• Is Part Of: Tetrahedron. Volume 104(2022)
• Publication Date: 2022-01-08
• Subjects: Catalyst-free -- One-pot synthesis -- Cascade reaction -- Isoindolobenzoxazinones -- Isoindoloquinazolinones; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2021.132571
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A practical and efficient catalyst-free cascade cyclization reaction of 2-acylbenzoic acids with various amino alcohols or diamines was developed. This protocol provides a powerful and straightforward method for the one-pot synthesis of diverse isoindolobenzoxazinones, isoindoloquinazolinones and their derivatives. The synthetic strategy evades the use of catalyst, shows a broad substrate scope and could be performed in gram-scale. Graphical abstract: Image 1