Synthesis and synthetic applications of (4-hydroxyphenyl)perfluoroalkylmethanols. (8th January 2022)

• Record Type: Journal Article
• Authors: Terashima, Kyu; Kawasaki-Takasuka, Tomoko; Minami, Ichiro; Yamazaki, Takashi
• Is Part Of: Tetrahedron. Volume 104(2022)
• Publication Date: 2022-01-08
• Subjects: Perfluoroalkyl -- Reduction -- p-quinone methide -- POSS; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2021.132574
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: Development of the convenient method for the synthesis of (hydroxyphenyl)perfluoro-alkylmethanols was achieved by the Meerwein-Ponndorf-Verley (MPV) type reduction of the in situ -generated perfluoroalkylated ketones as the key step. The benzylic OH group of the resultant alcohols was successfully converted to H or Rf(CH2 )n O by way of the corresponding chlorides, this transformation being not easy by any other methods. Graphical abstract: Image 1