Antibacterial activities of zeolite/silver-graphene oxide nanocomposite in bone implants. (19th September 2021)

• Record Type: Journal Article
• Authors: Abed, Solmaz; Bakhsheshi-Rad, Hamid Reza; Yaghoubi, Hashem; Ning, Liqun; Sadeghianmaryan, Ali; Chen, Xiongbiao
• Is Part Of: Materials technology. Volume 36:Number 11(2021)
• Page Start: 660
• Page End: 669
• Publication Date: 2021-09-19
• Subjects: Zeolite -- graphene oxide -- antibacterial activity -- biocompatibility; Materials -- Periodicals; Materials science -- Periodicals; Materials -- Technological innovations -- Periodicals; 620.1105
• DOI: 10.1080/10667857.2020.1786784
• Languages: English
• ISSNs: 1066-7857

Abstract

ABSTRACT: The capability to hinder microbial growth on the implant surfaces is of great interest in medical applications. This paper presents our study on the synthesis of zeolite/silver-graphene oxide (Zeo/Ag-GO) nanocomposite to enhance antibacterial activities of bone implants. Zeo/Ag-GO was synthesized using via semi-powder metallurgy and then characterized in terms of microstructure, antibacterial activities, and biocompatibility. Our microstructure results demonstrated that the Ag particles were anchored and uniformly distributed in the composite structure; assessment of antibacterial activity against the Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) revealed that Zeo/Ag-GO was better than Zeo/Ag, but Zeo has no antimicrobial activity observed; and biocompatibility assays showed that both Zeo/Ag and Zeo/Ag-GO had no negative effect on the proliferation of MG-63, while Zeo/Ag-GO promoted better cell viability. Taken together, Zeo/Ag-GO has great antimicrobial performance with suitable cytocompatibility, thus potentially being used to reduce implant-associated infections.