An aluminum lining to the dark cloud of silver resistance: harnessing the power of potent antimicrobial activity of γ-alumina nanoparticles. (29th October 2021)

• Record Type: Journal Article
• Authors: Dassanayake, Thiloka M.; Dassanayake, Arosha C.; Abeydeera, Nalin; Pant, Bishnu D.; Jaroniec, Mietek; Kim, Min-Ho; Huang, Songping D.
• Is Part Of: Biomaterials science. Volume 9:Number 23(2021)
• Page Start: 7996
• Page End: 8006
• Publication Date: 2021-10-29
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d1bm01233a
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : PEG-coated γ-Al2 O3 NPs obtained by the top-down sonication technique exhibit potent antibacterial activity and can overcome Ag resistance in the AgNP-treated bacterial mutants. Abstract : Although a biologically nonessential element in living organisms, aluminum is notably nontoxic to eukaryotic cells and has a venerable history of medicinal use. We demonstrate that polyethylene glycol-coated γ-alumina nanoparticles (Al2 O3 -NPs) with an average size of 15 nm prepared from a commercial bulk γ-alumina (γ-Al2 O3 ) via the top-down sonication technique exhibit antibacterial activity that is comparable to that of AgNPs against both the Gram-negative drug-susceptible Pseudomonas aeruginosa (DSPA) and multidrug-resistant Pseudomonas aeruginosa (DRPA) bacteria, while the antibacterial activity of such Al2 O3 -NPs considerably surpasses that of AgNPs against both the Gram-positive methicillin-susceptible Staphylococcus aureus (DSSA) and methicillin-resistant Staphylococcus aureus (MRSA) bacteria. We also demonstrate that the DSPA bacteria sequentially exposed to Al2 O3 -NPs for 30 days show no indication of resistance development. Furthermore, such Al2 O3 -NPs can completely overcome the drug resistance developed in the conventional antibiotic ciprofloxacin-resistant and AgNP-resistant mutants without developing Al resistance.