AB0564 Dry syndrome in ra patients. comparison with sjÖgren's syndrome patients. (12th June 2018)

• Record Type: Journal Article
• Authors: Peiteado, D.; Bonilla, G.; Montejano, R.; Boto, A.; Del Hierro, A.; Monjo, I.; Plasencia, C.; Balsa, A.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 1436
• Page End: 1437
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.6977
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objectives: The aim of the study is to analyse the clinical characteristics of Rheumatoid Arthritis (RA) patients and dry syndrome, and to compare with primary Sjögren's syndrome (PSS) patients. Methods: Patients with RA and dry syndrome derived from Rheumatology Clinic to Cornea Unit were evaluated. According to symptoms and ophthalmological examination, patients were classified as high or low probability of Sjögren Syndrome (SS). Clinical and laboratory assessments included sex, age and smoking habit, DAS28, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-citrullinated peptide antibodies (ACPA), antinuclear antibodies (ANA), anti Ro, anti La and presence of other extraarticular symptoms. In addition, the ophthalmological examination data (Ocular Staining Score [OSS] and Schirmer test), salivary gland scintigraphy (SGS) and salivary gland biopsy (biopsy) were analysed. The percentage of patients who would be classified according to the criteria of the Revised American-European Consensus Group (AECG) 2002, NIH-funded Sjögren's International Collaborative Clinical Alliance (SICCA) 2012 criteria and ACR/EULAR 2016 criteria is evaluated. RA patients with high probability of SS are compared with SSP patients. Statistics analysis was made by mean ±SD, and comparison was made by t- Student test (quantitative parameters) and non parametric test (qualitative) (p<0.05). Results: 24 RA with dry syndrome were included. 71% were women and the mean age was 64±14 years. The disease duration was 17±12 years. All patients had ocular manifestations, 2/3 oral manifestations, and 17% other extra-articular manifestations. According to DAS28, 33% of the patients were in clinical remission, 33% in high activity, and the others in low-moderate activity. 17 patients (71%), 19 (86%) and 5 (21%) were positive (+) for RF, ACPA and ANA, respectively. One patient had Anti Ro +and another anti La +. The mean OSS was 4.2 (±3.1) and the average of Schirmer was 10 (±11). In relation to other tests: 7 patients had a biopsy performed (2 positive [29%]), 5 patients had GGS (2 positive [40%]). 17 of the 24 RA patients (71%) were considered "high probability Sjögren's Syndrome" (SS and AR). These patients were compared with the PSS group (see table 1), showing differences in immunological parameters, sex, age and in the% that fulfilled the classification criteria. No significant differences were found in the ophthalmological examinations or the acute phase reactants. Conclusions: Most of this RA patients cohort with dry syndrome were considered as "high probability SS", however only a small percentage (12%–23%) fulfilled the classification criteria. This can be explained by the low rate of specific antibodies (6%), and by the poor performance of some tests included in the criteria. Disclosure of Interest: None declared