THU0364 Relationship between disease activity index scores and physician global assessment in early and non-early systemic lupus erythematosus. (12th June 2018)

• Record Type: Journal Article
• Authors: Garabajiu, M.; Sadovici-Bobeica, V.; Mazur-Nicorici, L.; Cebanu, M.; Salaru, V.; Mazur, M.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 399
• Page End: 399
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.3862
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objectives: To evaluate the disease activity and to compare it to physician's global assessment in patients with early (early SLE) and non-early systemic lupus erythematosus Methods: Performed case-control study included SLE patients that fulfilled .SLICC classification criteria, 2012. The research included two groups: patients with early SLE – first group (disease duration less than 24 months) and non-early SLE – second group (disease duration more than 24 months). The disease activity was assessed by SLEDAI-2K and SLAM. Physician global assessment (PhGA) was rated by 0–100 numeric score. We correlated disease activity indices with physician global assessment by Pearson coefficient. Results: A total of 96 SLE patients were analysed. First group included 45 patients with female:male ratio 14:1. The second group included 51 patients, female:male ratio 1:49. The disease activity indices: SLEDAI and SLAM denoted high disease activity level in both groups. PhGA didn't correlate with SLEDAI (r=0, 28, p>0, 05) in the first group, while a statistically significant correlation was determined with SLAM index (r=0, 39, p=0.007). In the second group we found a moderate statistical significant correlation of PhGA with SLAM (r=0, 53, p=0.0001) and weak, but also statistical significant relationship with SLEDAI (r=0, 35, p=0.01). There is a better correlation of PhGA assessment and SLAM in both study groups, which can be explained by the presence of subjective components in appreciation of this index. Patient's better appreciation of their condition in the group with longer disease duration (statistical significant correlation of PhGA and both indices:SLAM and SLEDAI), probably, is beacause this patients know better to appreciate their disease, and patients with early SLE tend to underestimate their general condition. Conclusions: In patients with early SLE PhGA correlated with SLAM, while in patients with non-early lupus PhGA correlated with both insices - SLAM and SLEDAI-2K. A better correlation of PhGA with SLAM can be esplained by the presence of multiple components in this tool and also subjective data as fatigue or cognitive disfunction. Disclosure of Interest: None declared