Catalyst-free, one-pot strategy to access 3-substituted-5-amino-1, 2, 4-thiadiazoles in water. Issue 23 (2nd December 2021)

• Record Type: Journal Article
• Authors: Nagaraju, Chaithra; Ashok, Swarup Hassan; Narayana, Yatheesh; Nagarakere, Sandhya C.; Kempegowda, Mantelingu; Kanchugarkoppal, Rangappa S.
• Is Part Of: Synthetic communications. Volume 51:Issue 23(2021)
• Page Start: 3610
• Page End: 3619
• Publication Date: 2021-12-02
• Subjects: Amidoximes -- catalyst-free -- isothiacyanates -- S–N bond formation -- 1, 2, 4-thiadiazole; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2021.1986840
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: A protocol has been devised for the synthesis of 3-substituted 5-amino-1, 2, 4-thiadiazoles utilizing isothiocyanates, amidoximes and water as an eco-friendly solvent. The strategy involves consecutive C−N and S−N bonds formation in a one-pot reaction under catalyst-free conditions. Operational simplicity, low cost, broad substrate scope and readily available starting materials are the main features of this protocol. Graphical Abstract: UF0001