Evaluation of the protective effects of curcumin and nanocurcumin against lung injury induced by sub-acute exposure to paraquat in rats. (2nd October 2021)

• Record Type: Journal Article
• Authors: Hosseini, Asieh; Rasaie, Danyal; Soleymani Asl, Sara; Nili Ahmadabadi, Amir; Ranjbar, Akram
• Is Part Of: Toxin reviews. Volume 40:Number 4(2021)
• Page Start: 1233
• Page End: 1241
• Publication Date: 2021-10-02
• Subjects: Curcumin -- nanocurcumin -- paraquat -- oxidative stress -- fibrosis -- lung; Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.1080/15569543.2019.1675707
• Languages: English
• ISSNs: 1556-9543

Abstract

Abstract: The aim of the current study is comparison the protective effects of curcumin and nanocurcumin against lung injury induced by sub-acute exposure with paraquat (PQ) through modulation of oxidative stress and gene expression. Oxidative stress biomarkers and genes expression were assessed by biochemical and RT-PCR analysis. Histopathological evaluation was performed by H&E staining. The results demonstrate that nanocurcumin to be superior to curcumin in protective effects on PQ-induced changes in mentioned factors. We found nanocurcumin had significantly more protective effect than curcumin to prevent the development of PQ-induced lung injury most probably via modulation of oxidative stress and gene expression.