3D‐Printed Regenerative Magnesium Phosphate Implant Ensures Stability and Restoration of Hip Dysplasia. Issue 21 (24th September 2021)

• Record Type: Journal Article
• Authors: Golafshan, Nasim; Willemsen, Koen; Kadumudi, Firoz Babu; Vorndran, Elke; Dolatshahi‐Pirouz, Alireza; Weinans, Harrie; van der Wal, Bart C. H.; Malda, Jos; Castilho, Miguel
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 21(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-24
• Subjects: 3D printing -- bone implants -- bone regeneration -- hip dysplasia -- load bearing -- patient‐specific implants; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202101051
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Osteoarthritis of the hip is a painful and debilitating condition commonly occurring in humans and dogs. One of the main causes that leads to hip osteoarthritis is hip dysplasia. Although the current surgical methods to correct dysplasia work satisfactorily in many circumstances, these are associated with serious complications, tissue resorption, and degeneration. In this study, a one‐step fabrication of a regenerative hip implant with a patient‐specific design and load‐bearing properties is reported. The regenerative hip implant is fabricated based on patient imaging files and by an extrusion assisted 3D printing process using a flexible, bone‐inducing biomaterial. The novel implant can be fixed with metallic screws to host bone and can be loaded up to physiological loads without signs of critical permanent deformation or failure. Moreover, after exposing the hip implant to accelerated in vitro degradation, it is confirmed that it is still able to support physiological loads even after losing ≈40% of its initial mass. In addition, the osteopromotive properties of the novel hip implant is demonstrated as shown by an increased expression of osteonectin and osteocalcin by cultured human mesenchymal stem cells after 21 days. Overall, the proposed hip implant provides an innovative regenerative and mechanically stable solution for hip dysplasia treatment. Abstract : One of the main causes for hip osteoarthritis is hip dysplasia. Currently, surgical methods to correct dysplasia have only limited success rates. Here, a regenerative hip implant with a patient‐specific design that can overcome the drawbacks with current treatments is reported. The implant is strong and resilient enough to bear physiological loads, is cytocompatible, and can stimulate in vitro bone growth.