Electrochemically controlled cocrystallisation of caffeine:1-hydroxy-2-naphthoic acid. Issue 1 (10th December 2021)

• Record Type: Journal Article
• Authors: Kaliszczak, Magdalena; Durand, Pierrick; Wenger, Emmanuel; Dossot, Manuel; Jones, Franca; Arrigan, Damien W. M.; Herzog, Grégoire
• Is Part Of: CrystEngComm. Volume 24:Issue 1(2022)
• Page Start: 48
• Page End: 51
• Publication Date: 2021-12-10
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/d1ce01281a
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : The formation of caffeine and 1-hydroxy-2-naphtoic acid cocrystals at a water–oil interface was controlled by potential difference, Δwo ϕ, favouring one polymorphic form of the cocrystal. Abstract : Controlled formation of cocrystals is an important objective in drug development. Here, cocrystallisation of caffeine and 1-hydroxy-2-naphthoic acid was investigated at the interface between two immiscible electrolyte solutions under chemical polarisation. In this way, selective cocrystallisation was achieved, as verified by X-ray diffraction and Raman spectroscopy. Positive interfacial potentials favoured the formation of one polymorphic form of caffeine:1-hydroxy-2-naphthoic acid cocrystal. This approach to electrochemically controlled cocrystallisation opens up new possibilities for drug development.