Secondary metabolites isolated from Agrimonia pilosa Ledeb. Issue 1 (22nd December 2021)

• Record Type: Journal Article
• Authors: Li, Hong-Rui; Li, Yu-Kui; Xiao, Jian; Yang, Cui; Jiang, Meng-Yuan; Tian, Kai; Wang, Wei; Li, Yan-Hong; Huang, Xiang-Zhong
• Is Part Of: Natural product research. Volume 36:Issue 1(2022)
• Page Start: 263
• Page End: 270
• Publication Date: 2021-12-22
• Subjects: Agrimonia pilosa Ledeb. -- phenylethyl isocoumarin glycoside -- anti-α-glucosidase activity -- anti-inflammatory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1779263
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A pilot study on the ethanol extracts of Agrimonia pilosa found to have anti- α -glucosidase and anti-inflammatory activities. Subsequent chemical study afforded a new phenylethyl isocoumarin glycoside (1 ) and eight known compounds (2-9 ). The structure of 1 was elucidated by comprehensive spectroscopic analysis and chemical transformations. All compounds showed modest α-glucosidase inhibitory activity (IC50 values ranging from 36.8 to 210.7 μM), which was lower than that of the positive control acarbose (IC50 =301.9 μM). Those compounds except inactive compounds 3 and 6 showed weak anti-inflammatory activity.