A new indole alkaloid from the stems of Glycosmis puberula var. craibii. Issue 1 (22nd December 2021)

• Record Type: Journal Article
• Authors: Zhou, Qi; Jiang, Chun-Xiao; Wu, Shou-Yuan; Chen, Zi-Ming; Huang, Li-Ping
• Is Part Of: Natural product research. Volume 36:Issue 1(2022)
• Page Start: 379
• Page End: 384
• Publication Date: 2021-12-22
• Subjects: Glycosmis puberula var. craibii -- indole alkaloid -- glycosmiscrol A -- antiproliferative activities; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1788024
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A phytochemical investigation on the stems of Glycosmis puberula var. craibii led to the isolation of a new indole alkaloid (named glycosmiscrol A, 1 ), together with four known compounds (2 –5 ). The new structure was elucidated by detailed analysis of comprehensive spectroscopic methods. All isolated compounds were evaluated for their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro . Compounds 1 –5 showed significant antiproliferative effects with IC50 values ranging from 0.16 to 8.58 µM. Abstract : UF0001