Macrotricolorin A, a new diarylpropanoid from the Vietnamese plant Macrosolen tricolor (Lecomte) Danser. Issue 1 (22nd December 2021)

• Record Type: Journal Article
• Authors: Le, Kieu Hung; Bui, Thi Kim Ngan; Pham, Nguyen Kim Tuyen; Dang, Van Son; Ngo, Trong Nghia; Phan, Nhat Minh; Bui, Trong Dat; Tran, Trong Duc; Nguyen, Quan Hien; Ngo, Quoc Luan; Mai, Dinh Tri; Nguyen, Tan Phat
• Is Part Of: Natural product research. Volume 36:Issue 1(2022)
• Page Start: 165
• Page End: 170
• Publication Date: 2021-12-22
• Subjects: Macrosolen tricolor -- Loranthaceae -- diarylalkanoid -- macrotricolorin A -- anti-inflammatory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1771710
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: From the Vietnamese plant Macrosolen tricolor (Lecomte) Danser, one new diarylpropanoid, named macrotricolorin A (1 ) together with three diarylheptanoids including bisdemethoxycurcumin (2 ), demethoxycurcumin (3 ) and curcumin (4 ), were isolated. Their structures were elucidated by intensive analyses of their IR, UV, HR-ESI-MS and NMR (1 D & 2 D) spectra. It is the first time that diarylalkanoids have been reported from the genus Macrosolen. Compound 1 exhibited anti-inflammatory activity against the nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 with an IC50 value of 27.54 ± 1.75 μM. Graphical Abstract: UF0001