Two new nor-lignans from Selaginella pulvinata (Hook. & Grev.) Maxim and their antihyperglycemic activities. Issue 1 (22nd December 2021)

• Record Type: Journal Article
• Authors: Lv, Hua-Wei; Li, Yu-Xia; Luo, Meng; Qi, Jia-Meng; Fu, Ze-Fei; Zhang, Hong-Jian; Guo, Yuan-Qiang; Chu, Chu; Li, Han-Bing; Yan, Ji-Zhong
• Is Part Of: Natural product research. Volume 36:Issue 1(2022)
• Page Start: 279
• Page End: 286
• Publication Date: 2021-12-22
• Subjects: Pulvin A -- moellenoside C -- Selaginella pulvinate (Hook. & Grev.) Maxim -- Selaginellaceae -- antihyperglycemic activity -- 3T3-L1 adipocyte; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1779267
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new nor -lignans, pulvin A (1 ) and moellenoside C (2 ), along with two known compounds (3 –4 ) were isolated from the whole plant of Selaginella pulvinate (Hook. & Grev.) Maxim. The structures of the new compounds were established on the basis of spectroscopic data and acid hydrolysis. All the isolates were investigated for their antihyperglycemic activities in 3T3-L1 adipocytes. The results showed that compounds 1 and 2 promoted the glucose consumption prominently in 3T3-L1 adipocytes in a dose-response manner. Compound 1 and 2 induced 1.14–1.73 folds and 1.03–1.55 folds changes relative to the basal level, respectively, in the concentration range of 12.5 μM to 50 μM. Abstract : UF0001