Combinational exposure to Bisphenol A and a high-fat diet causes trans-generational Malfunction of the female reproductive system in mice. (5th February 2022)

• Record Type: Journal Article
• Authors: Huang, Rongfeng; Li, Jiayu; Liao, Maolin; Ma, Li; Laurent, Irakoze; Lin, Xiaojing; Zhang, Yunqi; Gao, Rufei; Ding, Yubin; Xiao, Xiaoqiu
• Is Part Of: Molecular and cellular endocrinology. Volume 541(2022)
• Publication Date: 2022-02-05
• Subjects: Bisphenol A -- High-fat diet -- Endocrine disrupter -- Female reproductive system -- Trans-generational effects; BPA Bisphenol A -- HFD high-fat diet -- GnRH Gonadotropin-releasing hormone -- LH luteinizing hormone -- FSH follicle-stimulating hormone -- LFD low-fat diet -- PND21 postnatal day 21 -- MYO myometrium -- ENDO endometrium; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2021.111507
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: Bisphenol A (BPA) is a common endocrine disruptor and a high-fat diet (HFD) also affects fertility. However, little is known about the long-term consequences of simultaneous exposure to BPA and a HFD on reproductive health. Herein, we assessed the effects of maternal exposure to BPA in combination with a HFD on reproductive function in subsequent generations of female mice and evaluated its effects on the hypothalamic-pituitary-gonadal axis. We found that the combination of maternal exposure to BPA and a HFD led to increased urine BPA levels, precocious puberty, altered estrous cyclicity, decreased follicle numbers, and altered hypothalamic Kiss1 methylation status in F1 and F2 mice. Therefore, we demonstrated that maternal exposure to BPA in combination with a HFD exerts a trans-generational effect on female reproduction. Highlights: BPA exerts toxic effects on reproduction and other physiological functions. Combined maternal BPA and HFD exposure increases urine BPA levels. Maternal exposure to BPA and a HFD induced dystocia and prolonged pregnancy. Mice exposed to BPA alone showed high infertility rates. HFD exacerbates the reproductive dysfunction caused by chronic BPA exposure.