Sleep apnea in total joint arthroplasty patients and the role for cardiac biomarkers for risk stratification: an exploration of feasibility. (March 2016)

• Record Type: Journal Article
• Authors: Lyons, M Melanie; Bhatt, Nitin Y; Kneeland-Szanto, Elizabeth; Keenan, Brendan T; Pechar, Joanne; Stearns, Branden; Elkassabany, Nabil M; Memtsoudis, Stavros G; Pack, Allan I; Gurubhagavatula, Indira
• Is Part Of: Biomarkers in medicine. Volume 10:Number 3(2016)
• Page Start: 265
• Page End: 300
• Publication Date: 2016-03
• Subjects: brain natriuretic peptide -- obstructive sleep apnea -- postoperative complications -- total joint arthroplasty -- troponin; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.16.1
• Languages: English
• ISSNs: 1752-0363

Abstract

Obstructive sleep apnea (OSA) is highly prevalent in patients undergoing total joint arthroplasty (TJA) and is a major risk factor for postoperative cardiovascular complications and death. Recognizing this, the American Society of Anesthesiologists urges clinicians to implement special considerations in the perioperative care of OSA patients. However, as the volume of patients presenting for TJA increases, resources to implement these recommendations are limited. This necessitates mechanisms to efficiently risk stratify patients having OSA who may be susceptible to post-TJA cardiovascular complications. We explore the role of perioperative measurement of cardiac troponins (cTns) and brain natriuretic peptides (BNPs) in helping determine which OSA patients are at increased risk for post-TJA cardiovascular-related morbidity.