Sarcoidosis among US Hispanics in a Nationwide Registry. (December 2021)

• Record Type: Journal Article
• Authors: Innabi, Ayoub; Alzghoul, Bashar N.; Kalra, Saminder; Al-Hakim, Tamara; Buchanan, Mindy; Shivas, Tricha; Xue, Wei; Gomez-Manjarres, Diana; Patel, Divya C.
• Is Part Of: Respiratory medicine. Volume 190(2022)
• Publication Date: 2021-12
• Subjects: Sarcoidosis -- Hispanics -- Ethnicity; ACCESS A Case Controlled Etiologic Study of Sarcoidosis -- aOR Adjusted Odd Ratio -- BIPAP Bilevel Positive Airway Pressure -- CPAP Continuous Positive Airway Pressure -- FSR Foundation for Sarcoidosis Research -- IVIG Intravenous Immunoglobulin -- SARC Sarcoidosis Advanced Registry for Cures -- TNF Tumor Necrosis Factor -- US United States; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2021.106682
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Background: Sarcoidosis has been well studied in multiple races and ethnic groups. However, there is a paucity of data that describes sarcoidosis in Hispanics. We aimed to determine the prevalence of Hispanic ethnicity, clinical characteristics and impact of sarcoidosis among Hispanics from a US based national registry. Methods: We conducted a national registry-based study investigating 3835 respondents to the Sarcoidosis Advanced Registry for Cures questionnaire. This registry is a web-based, self-reported questionnaire that provides data related to demographics, diagnostics, organ involvement, treatment modalities, and the physical and psychosocial impact of sarcoidosis. We compared Hispanic patients to non-Hispanics. We performed multivariate logistic regression analysis adjusting for age, gender, education, income and insurance status and looked at the association between Hispanic ethnicity with depression, chronic pain syndrome, chronic fatigue syndrome, impact on family finances, employment-based disability and job termination. Results: Nine percent of the patients reported a Hispanic ethnicity and the majority of these patients self-identified as white women. The most common organs involved were the lungs (74.9%), central lymph nodes (53.8%), and peripheral lymph nodes (37.1%). Hispanics reported more peripheral nerves and peripheral lymph nodes involvement than non-Hispanics. Hispanics experienced more depression, sleep apnea, and chronic pain syndrome than non-Hispanics. The use of mobility assistive devices was more common among Hispanics, as well as employment-based disability, and disease-related job termination compared to non-Hispanics. The majority of Hispanics reported significantly more pain that interfered with the enjoyment of life than non-Hispanics. On multivariate logistic regression analysis, Hispanic ethnicity was associated with depression (adjusted odds ratio (aOR) = 1.5; 95% CI: 1.01–2.2), chronic pain syndrome (aOR = 1.7; 1.1–2.6), job termination due to sarcoidosis (aOR = 1.7; 1.1–2.7) and higher impact on family finances (aOR = 1.7; 1.1–2.5). Conclusion: The clinical presentation of sarcoidosis in Hispanic patients differs from that in non-Hispanic patients living in the United States. These differences should be considered when managing Hispanic patients with sarcoidosis. We encourage more studies that investigate phenotyping among Hispanics with sarcoidosis. Highlights: 9% of patients in the FSR-SARC cohort identified themselves as Hispanic. Extrapulmonary involvement was common in the Hispanics group. Non-organ related manifestations such as depression, sleep disturbances and chronic pain were more common in the Hispanic group. Hispanic ethnicity was associated with more depression, chronic pain syndrome, job termination due to sarcoidosis and higher impact on family finances.