A hydrogel with supramolecular surface functionalization for cancer cell capture and multicellular spheroid growth and release. Issue 5 (17th December 2021)

• Record Type: Journal Article
• Authors: Wen, Yuting; Mensah, Nana Nyarko; Song, Xia; Zhu, Jingling; Tan, Wui Siew; Chen, Xinwei; Li, Jun
• Is Part Of: Chemical communications. Volume 58:Issue 5(2022)
• Page Start: 681
• Page End: 684
• Publication Date: 2021-12-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc05846k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A hydrogel scaffold with a non-fouling but specific cancer cell-adhesive surface fabricated via host–guest interactions captures cancer cells and promotes growth and release of multicellular spheroids. Abstract : A hydrogel scaffold with a non-fouling but specific cancer cell-adhesive surface was fabricated through surface modification using β-cyclodextrin-based host–guest chemistry. Interestingly, the hydrogel surface not only selectively captured specific cancer cells, but also grew the cells into multicellular spheroids. The spheroids could be released without damaging the cell viability through replacing the host moieties on the scaffold, and the released spheroids showed no changes in size or morphology.