A genome-wide association study for varicose veins. (May 2022)

• Record Type: Journal Article
• Authors: Lee, Meng-Lin; Liang, Chao; Chuang, Cheng-Hsun; Lee, Pei-Shyuan; Chen, Thay-Hsiung; Sun, Shen; Liao, Kuang-Wen; Huang, Hsien-Da
• Is Part Of: Phlebology. Volume 37:Number 4(2022)
• Page Start: 267
• Page End: 278
• Publication Date: 2022-05
• Subjects: Varicose vein -- single nucleotide polymorphism (SNP) -- genome wide association study -- Clinical-Etiology-Anatomy-Pathophysiology classification; Veins -- Diseases -- Periodicals; 616.14
• DOI: 10.1177/02683555211069248
• Languages: English
• ISSNs: 0268-3555

Abstract

Background: The aim was to compare the genetic information of varicose vein patients with that of a healthy population attempting to identify certain significant genetic associations. Method: Patients' clinical characteristics and demographics were collected, and their genetic samples were examined. The results were compared to the genetic information of one thousand sex-matched healthy controls from Taiwan Biobank database. The Clinical-Etiology-Anatomy-Pathophysiology classification was applied for further subgroup analysis. Results: After comparison of genetic information of ninety-six patients to that of healthy controls, two significant single nucleotide polymorphisms (SNPs) were identified. One was in DPYSL2 gene, and the other was in VSTM2L gene. A further comparison between C2-3 patient subgroup and C4-6 subgroup identified another four significant SNPs, which were located in ZNF664-FAM101A, PHF2, ACOT11, and TOM1L1 genes. Conclusion: Our preliminary result identified six significant SNPs located in six different genes. All of them and their genetic products may warrant further investigations.