Connectome-based model predicts individual psychopathic traits in college students. (19th January 2022)

• Record Type: Journal Article
• Authors: Ye, Shuer; Zhu, Bing; Zhao, Lei; Tian, Xuehong; Yang, Qun; Krueger, Frank
• Is Part Of: Neuroscience letters. Volume 769(2022)
• Publication Date: 2022-01-19
• Subjects: Psychopathic traits -- Connectome-based predictive modeling -- Resting-state functional connectivity; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2021.136387
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Whole-brain RSFC predict total and secondary psychopathic traits in college students. The most connected nodes are mainly anchored in the prefrontal cortex and limbic system. The OCCN-CON connections contribute most to the predictive connectomes. Abstract: Background: Psychopathic traits have been suggested to increase the risk of violations of socio-moral norms. Previous studies revealed that abnormal neural signatures are associated with elevated psychopathic traits; however, whether the intrinsic network architecture can predict psychopathic traits at the individual level remains unclear. Methods: The present study utilized connectome-based predictive modeling (CPM) to investigate whether whole-brain resting-state functional connectivity (RSFC) can predict psychopathic traits in the general population. Resting-state fMRI data were collected from 84 college students with varying psychopathic traits measured by the Levenson Self-Report Psychopathy Scale (LSRP). Results: Functional connections that were negatively correlated with psychopathic traits predicted individual differences in total LSRP and secondary psychopathy score but not primary score. Particularly, nodes with the most connections in the predictive connectome anchored in the prefrontal cortex (e.g., anterior prefrontal cortex and orbitofrontal cortex) and limbic system (e.g., anterior cingulate cortex and insula). In addition, the connections between the occipital network (OCCN) and cingulo-opercular network (CON) served as a significant predictive connectome for total LSRP and secondary psychopathy score. Conclusion: CPM constituted by whole-brain RSFC significantly predicted psychopathic traits individually in the general population. The brain areas including the prefrontal cortex and limbic system and large-scale networks including the CON and OCCN play special roles in the predictive model—possibly reflecting atypical cognitive control and affective processing for individuals with elevated psychopathic traits. These findings may facilitate detection and potential intervention of individuals with maladaptive psychopathic tendency.