Canine coat pigmentation genetics: a review. (9th November 2021)

• Record Type: Journal Article
• Authors: Brancalion, L.; Haase, B.; Wade, C. M.
• Is Part Of: Animal genetics. Volume 53:Number 1(2022)
• Page Start: 3
• Page End: 34
• Publication Date: 2021-11-09
• Subjects: albinism -- coat colour -- deafness -- dog -- melanocyte -- melanogenesis -- pigmentation; Animal genetics -- Periodicals; 572.8
• DOI: 10.1111/age.13154
• Languages: English
• ISSNs: 0268-9146

Abstract

Summary: Our understanding of canine coat colour genetics and the associated health implications is developing rapidly. To date, there are 15 genes with known roles in canine coat colour phenotypes. Many coat phenotypes result from complex and/or epistatic genetic interactions among variants within and between loci, some of which remain unidentified. Some genes involved in canine pigmentation have been linked to aural, visual and neurological impairments. Consequently, coat pigmentation in the domestic dog retains considerable ethical and economic interest. In this paper we discuss coat colour phenotypes in the domestic dog, the genes and variants responsible for these phenotypes and any proven coat colour‐associated health effects.