An electrochemical molecularly imprinted sensor based on CuBi2O4/rGO@MoS2 nanocomposite and its utilization for highly selective and sensitive for linagliptin assay. (March 2022)

• Record Type: Journal Article
• Authors: Mehmandoust, Mohammad; Erk, Nevin; Karaman, Ceren; Karaman, Onur
• Is Part Of: Chemosphere. Volume 291:Part 1(2022)
• Publication Date: 2022-03
• Subjects: Molecularly imprinted polymers -- Linagliptin -- Screen-printed carbon electrode -- Reduced graphene oxide -- CuBi2O4 -- MoS2; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2021.132807
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: The molecularly imprinted polymers (MIP) is an outstanding electrochemical tool that demonstrates good chemical sensitivity and stability. These main advantages, coupled with the material's vast microfabrication flexibility, make molecularly imprinted sensors an attractive sensing device. Herein, it was aimed to develop a state-of-art molecularly imprinted sensor based on CuBi2 O4 /rGO@MoS2 nanocomposite to be utilized for the detection of linagliptin (LNG), a novel hypoglycemic drug. The electrochemical characterizations of linagliptin on the surface of the modified electrode was examined via cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). Several characterization methods including transmission electron microscope (TEM), X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and Energy-dispersive X-ray spectroscopy(EDX), were utilized for electrode characterization. The LNG imprinted voltammetric sensor was developed in 80.0 mM phenol containing 20.0 mM LNG. CuBi2 O4 /rGO@MoS2 nanocomposite on LNG imprinted screen-printed carbon electrode (SPCE) (MIP/CuBi2 O4 /rGO@MoS2 nanocomposite/SCPE) exhibited a linear relationship between peak current and LNG concentration in the range 0.07–0.5 nM with a detection limit of 0.057 nM. In the existence of interfering substances, an LNG imprinted electrode was utilized to analyze urine, human plasma, and tablet samples with adequate selectivity. The developed sensor was also illustrated for stability, repeatability, reproducibility, and reusability. Graphical abstract: Image 1 Highlights: Fabrication of platform for linagliptin detection reported. The oxidation current of linagiliptin enhanced on MIP/CuBi2 O4 /rGO@MoS2 /SCPE. The developed sensor exhibited high sensitivity and nano-molar detection limits. The application of the fabricated electrode for real samples was also investigated.