A History of Mild Traumatic Brain Injury Is Associated With a a More Severe Long-term Migraine Phenotype. (4th January 2022)

• Record Type: Journal Article
• Authors: Ishii, Ryotaro; Dodick, David W.; Trivedi, Meesha; Dumkrieger, Gina; Schwedt, Todd J.
• Is Part Of: Neurology. Volume 98:Number 1(2022)Supplement 1
• Page Start: S1
• Page End: S3
• Publication Date: 2022-01-04
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/01.wnl.0000801752.54157.d2
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : Objective: This study aimed to investigate the effect of prior mTBI on the clinical features and disability in patients presenting with migraine. Background: Head injury is a risk factor for chronic migraine (CM) and migraine is a risk factor for persistent headache after mild traumatic brain injury (mTBI). Design/Methods: Of 2, 161 migraine patients without a diagnosis of post-traumatic headache (PTH) who participated in the American Registry for Migraine Research (ARMR) between February 2016 and March 2020, 1, 120 answered questions about a history of mTBI. After controlling for age, gender, and having CM, demographics, headache characteristics, Patient Health Questionnaire-2 (PHQ-2) score, General Anxiety Disorder-7 (GAD-7) grade, and Migraine Disability Assessment Scale (MIDAS) scores were compared between those with a history of mTBI to those without. Results: Among 1, 098 migraine patients, 37.6% ( n = 413) had a history of mTBI. The patients with mTBI were more likely to have CM ( p = 0.004), dizziness ( p = 0.003), vertigo ( p = 0.009), and difficulty finding words ( p < 0.001). Patients with mTBI had significantly greater scores on the MIDAS (58.6 ± 52.6 vs 50.0 ± 47.8, p = 0.034) and PHQ-2 (1.6 ± 1.8 vs 1.3 ± 1.6, p = 0.012), and had significantly higher proportion of moderate to severe GAD-7 grade (21.7% vs 17.1%, p = 0.017) compared to those without mTBI. Conclusions: In patients presenting with migraine, a prior history of mTBI was associated with a diagnosis of chronic migraine, disability, anxiety and depression severity, as well as dizziness, vertigo, and word finding difficulty. A history of mTBI should be assessed in patients presenting with migraine, and people with migraine who have a high exposure risk to mTBI, should be aware of the potential for migraine progression and psychiatric symptoms after mTBI.