Blood flow rate and wall shear stress in seven major cephalic arteries of humans. Issue 3 (11th November 2019)

• Record Type: Journal Article
• Authors: Seymour, Roger S.; Hu, Qiaohui; Snelling, Edward P.
• Is Part Of: Journal of anatomy. Volume 236:Issue 3(2020)
• Page Start: 522
• Page End: 530
• Publication Date: 2019-11-11
• Subjects: artery -- brain -- cardiovascular -- cerebral -- da Vinci's Rule -- Murray's Law; Anatomy -- Periodicals; 571.3
• DOI: 10.1111/joa.13119
• Languages: English
• ISSNs: 0021-8782

Abstract

Abstract: Blood flow rate ( Q ˙ ) in relation to arterial lumen radius ( ri ) is commonly modelled according to theoretical equations and paradigms, including Murray's Law ( Q ˙ ∝ r i 3 ) and da Vinci's Rule ( Q ˙ ∝ r i 2 ). Wall shear stress ( τ ) is independent of ri with Murray's Law ( τ ∝ r i 0 ) and decreases with da Vinci's Rule ( τ ∝ r i - 1 ). These paradigms are tested empirically with a meta‐analysis of the relationships between Q ˙ and ri in seven major arteries of the human cephalic circulation from 19 imaging studies in which both variables were presented. The analysis shows that Q ˙ ∝ r i 2.16 and τ ∝ r i - 1.02, more consistent with da Vinci's Rule than Murray's Law. This meta‐analysis provides standard values for Q ˙, ri and τ in the human cephalic arteries that may be a useful baseline in future investigations. On average, the paired internal carotid arteries supply 75%, and the vertebral arteries supply 25%, of total brain blood flow. The internal carotid arteries contribute blood entirely to the anterior and middle cerebral arteries and also partly to the posterior cerebral arteries via the posterior communicating arteries of the circle of Willis. On average, the internal carotid arteries provide 88% of the blood flow to the cerebrum and the vertebral arteries only 12%. Abstract : A meta‐analysis of blood flow rate and arterial radius for seven major cephalic arteries provides normal values for adult humans. The relationships reveal that mean flow rate scales with radius to the power of approximately 2 and that wall shear stress scales with radius to approximately −1. The hypothetical exponents would be 3 and 0, respectively, if wall shear stress were constant, according to Murray's Law. Thus the flow regimen is more consistent with da Vinci's Rule.